Tim-3在乳腺癌中的作用

The Role of Tim-3 in Breast Cancer

乳腺癌是女性中最常见的癌症,死亡率极高。尽管乳腺癌的治疗方法取得了许多进展,但其高度异质性和侵袭转移能力使得临床上迫切需要新的治疗策略与思路。随着免疫检查点封闭疗法的兴起,T细胞免疫球蛋白及黏蛋白结构域分子3(Tim-3)走进人们的视野。Tim-3作为免疫检查点分子,在乳腺癌的发展中起着重要作用。Tim-3可用于乳腺癌治疗效果的评估,抗Tim-3抗体及其他抑制剂对乳腺癌的治疗在临床前研究中已取得成效。该综述总结了有关Tim-3的表达机制及其在乳腺癌中的作用,并讨论了Tim-3作为乳腺癌治疗靶点的基本原理以及Tim-3在乳腺癌中的潜在治疗方案。

Breast cancer is the most common cancer among women,with a very high mortality rate.Although many advances have been made in the treatment of breast cancer,its high degree of heterogeneity and ability of invasion and metastasis make the clinical urgent need for new treatment strategies and ideas.With the rise of immune checkpoint blocking therapy,Tim-3 (T cell immunoglobulin and mucin domain molecule 3) entered people’s field of vision.Tim-3,as an immune checkpoint molecule,plays an important role in the development of breast cancer.Tim-3 can be used to evaluate the effect of breast cancer treatment.Anti-Tim-3 antibodies and other inhibitors have been effective in the treatment of breast cancer in preclinical studies.This review summarizes the expression mechanism of Tim-3 and its role in breast cancer,and discusses the basic principles of Tim-3 as a breast cancer treatment target and potential treatment options for Tim-3 in breast cancer.