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牙周炎患者Hp生长分布对口腔环境及牙周膜细胞成骨能力影响 被引量:1

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摘要 目的探讨牙周炎患者Hp生长分布对口腔环境及牙周膜细胞成骨能力影响。方法将120例牙周炎患者作为观察组,另选取30名同期于我院行口腔检查证实为牙周健康者作为对照组,采用PCR检测口腔Hp分布情况,检测两组的口腔环境,采用RT-PCR法检测ALP、Runx-2表达情况。结果观察组的口腔Hp阳性率显著高于对照组(P<0.05);重度牙周炎患者的口腔Hp阳性率显著高于轻度者(P<0.05);Hp阳性者的牙周袋深度、龈沟液pH值、菌斑指数均高于Hp阴性(P<0.05),观察组显著高于对照组(P<0.05);观察组HP阳性者的ALP、Runx-2 mRNA水平显著低于Hp阴性者(P<0.05);观察组的ALP、Runx-2 mRNA水平显著低于对照组(P<0.05)。结论牙周炎患者Hp生长与口腔环境密切相关,pH值偏高及牙菌斑数目增多更适合Hp生长,牙周炎患者的ALP、Runx-2表达下降,牙周膜细胞成骨能力减弱,Hp感染可能不是牙周膜细胞成骨能力下降的直接因素。
出处 《贵州医药》 CAS 2021年第4期575-576,共2页 Guizhou Medical Journal
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