补充益生菌对功能性腹泻患者焦虑抑郁状态的影响

Effect of probiotic supplementation on anxiety and depression in patients with functional diarrhea

目的探讨益生菌对功能性腹泻患者临床症状和心理健康的影响。方法将2019年3月至2019年12月在广东省肇庆市高要区人民医院消化内科门诊收治的伴有焦虑抑郁状态的90例功能性腹泻住院病人随机分为试验组、对照组A、对照组B。三组受试者均口服匹维溴铵,试验组口服双歧杆菌四联活菌,对照组A服用氟西汀,对照组B未给其他药物治疗,疗程均为1个月。治疗前后,比较患者大便次数及性状、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分。结果治疗前三组患者每周排便不同次数的人数比较,差异无统计学意义(P>0.05)。治疗第3周和第4周后,与对照组A相比,对照组B和试验组的排便不同次数的人数差异具有统计学意义(P<0.05)。治疗第4周后,试验组与对照组B的排便不同次数的人数比较,差异具有统计学意义(P<0.05)。治疗前3组患者Bristol粪便性状评分比较差异无统计学意义(P>0.05)。治疗第3和第4周后,与对照组A相比,对照组B和试验组的Bristol粪便性状评分比较,差异有统计学意义(P<0.05)。治疗第4周后,试验组与对照组B的Bristol粪便性状评分比较,差异有统计学意义(P<0.05)。治疗后与对照组A比较,对照组B和试验组HAMA评分和HAMD评分显著低于对照组A,且差异具有统计学意义(P<0.05)。与对照组B比较,试验组HAMA评分和HAMD评分显著低于对照组B(P<0.05)。结论通过补充益生菌可调节功能性腹泻患者腹泻次数,提高功能性腹泻患者生活质量,改善患者焦虑抑郁症状。

Objective To observe the effect of probiotics on clinical symptoms and mental health of patients with functional diarrhea. Methods Ninety hospitalized patients with functional diarrhea with anxiety and depression in our hospital from March 2019 to December 2019 enrolled and randomly divided into the observation group, control group A or control group B. All the subjects were given pivonium bromide orally;the observation group was additionally given Bifidobacterium bifidum tetrameter, while the control group A was given fluoxetine. The control group B was not given any other drugs. The treatment course was one month. Before and after treatment, the defecation frequency and characteristics of stool, Hamilton anxiety scale(HAMA) and Hamilton depression scale(HAMD) scores of the patients were compared among groups. Results Before treatment, there were no significant differences in the frequency of defecation among the three groups(P>0.05). After 3 and 4 weeks of treatment, compared with the control group A, the frequencies of defecation in the control group B and the observation group were significantly different(P<0.05). After 4 weeks of treatment, there was a significant difference in the frequency of defecation between the observation group and the control group B(P<0.05). Before treatment, there was no significant difference in Bristol stool character score among the three groups(P>0.05). After 3 and 4 weeks of treatment, compared with control group A, the Bristol stool character scores in control group B and observation group were statistically significant(P<0.05). After 4 weeks of treatment, the Bristol stool character scores in observation group and control group B were statistically significant(P<0.05). After treatment, compared with control group A, the HAMA scores and HAMD scores in control group B and observation group were significantly lower(all P<0.05);compared with control group B, the HAMA score and HAMD score in observation group were significantly lower(P<0.05). Conclusion Probiotics supplementation can regulate the frequency of diarrhea in patients with functional diarrhea, improve the quality of life of the patients, as well as the symptoms of anxiety and depression.