活性氧介导的肿瘤微环境在胰腺癌发生与发展中作用的研究进展

Progress on the role of reactive oxygen species-mediated tumor microenvironment in pancreatic cancer

胰腺癌是一种在全世界范围内发病率和死亡率都很高的恶性肿瘤,当前缺少有效的手术方法和治疗药物。近年来,活性氧(reactive oxygen species,ROSs)已成为胰腺癌研究领域的热点。ROSs可调节肿瘤微环境(tumor microenvironment,TME)、肿瘤干细胞(cancer stem cells,CSCs)更新和上皮-间质转化(epithelial-mesenchymal transition,EMT)等过程,从而导致胰腺癌的耐药和复发。当前,包括免疫浸润、成纤维细胞、血管和细胞外基质在内的TME已成为肿瘤研究的热点。同时,已有大量文献报道ROSs介导的TME在胰腺癌的发生与发展中具有重要的作用,靶向调节ROSs可能是治疗胰腺癌的一种方法。因此,本文综述了ROSs在胰腺癌肿瘤发生和耐药中的调控作用、ROSs在胰腺癌信号转导中的作用以及ROSs在胰腺癌基质细胞中的作用,并总结了靶向调节ROSs的抗胰腺癌的潜在药物。

Pancreatic cancer(PC)is a devastating malignant tumor with high incidence and mortality rate worldwide.Meanwhile,the surgical approaches and drugs of this disease remain challenging.In recent years,reactive oxygen species(ROSs)study has become a hotspot in the field of PC research.ROSs may regulate tumor microenvironment(TME),cancer stem cells(CSCs)renewal and epithelial-mesenchymal transition(EMT),which result in drug-resistance and recurrence of the PC.Currently,TME that includes immune infiltrates,fibroblasts,vascular vessels and extracellular matrix has become a hotspot in the cancer research.Meanwhile,numerous researches have shown that ROSs-mediated TME plays a central role in the occurrence and development of PC.Targeting ROSs may be promising therapeutic treatments for the PC patients.Therefore,the purposes of the review were manifold:(1)to summarize the regulations of ROSs in tumorigenesis and drug-resistance of PC;(2)to investigate the modulation of ROSs in signaling cascades in PC;(3)to study the effects of ROSs in stromal cells in PC;(4)to generalize the potent therapies targeting ROSs in PC.Overall,this review summarized the current status of ROSs in PC research and suggested some potential anti-PC drugs that may target ROSs.