中药干预慢性心力衰竭心肌细胞凋亡的研究进展

Research progress of traditional Chinese medicine interfering cardiomyocyte apoptosis in chronic heart failure

心肌细胞凋亡是心力衰竭的重要病理变化,是心衰从代偿走向失代偿的转折点。中药在调控心衰心肌细胞凋亡中发挥着重要作用,已成为现阶段的研究热点。中药主要通过调控相关凋亡因子及信号通路(线粒体信号通路、死亡受体信号通路、内质网信号通路、Hippo通路、Bcl-2家族、caspase家族、p53等),发挥抑制心肌细胞凋亡的作用,从而改善心脏功能,保护心肌组织。本文主要对与中药作用密切相关的细胞凋亡途径及凋亡因子进行了综述,为临床治疗慢性心衰提供可靠的实验依据。

Cardiomyocyte apoptosis is an important pathological change of heart failure(HF),which is the turning point of HF from compensation to decompensation.Traditional Chinese medicine(TCM)plays an important role in regulating the apoptosis of HF cells,which has become a research hot spot.It mainly regulates related apoptosis factors and signaling pathways including mitochondrial signaling pathway,death receptor signaling pathway,endoplasmic reticulum signaling pathway,Hippo pathway,Bcl-2 family,CytoC,caspase family,p53,and so on,which improve heart function,protect myocardial tissue and delay ventricular remodeling.This paper mainly reviews the apoptotic pathways and apoptotic factors closely related to the effects of TCM and provides reliable experimental basis for the clinical treatment of chronic HF.