梅尼埃病者补体、免疫球蛋白与听觉前庭功能关系及诊断价值

Relationship between complement,immunoglobulin and auditory vestibular function in patients with Meniere’s disease and its diagnostic value

目的探讨梅尼埃病(MD)患者补体、免疫球蛋白(Ig)与听觉前庭功能关系及诊断价值。方法选取2017年9月至2020年9月本院收治的102例MD患者为MD组,另选取同期39例健康人群为对照组,比较两组基线资料、听觉前庭功能[前庭功能减数值、语音频率、听觉脑干诱发电位(ABR)Ⅰ~Ⅴ波间歇期]、C3、C4、IgA、IgG、IgM,分析MD的相关影响因素,评价补体、免疫球蛋白与听觉前庭功能的关系及对MD的诊断价值。结果前庭功能减数值、语音频率、ABRⅠ~Ⅴ波间歇期、C3、C4、IgA、IgG、IgM比较,MD组>对照组,差异有统计学意义(P<0.05);C3、C4、IgA、IgG、IgM与MD患者前庭功能减数值、语音频率、ABRⅠ~V波间歇期呈正相关(P<0.05);C3、C4、IgA、IgG、IgM是MD发生的重要影响因素(P<0.05);C3、C4、IgA、IgG、IgM联合诊断MD的曲线下面积(AUC)最大,为0.945。结论补体、Ig与MD患者听觉前庭功能存在良好线性关系,二者联合检测可为临床MD诊断、听觉前庭功能评估提供有效辅助手段。

Objective To investigate the relationship between complement,immunoglobulin(Ig)and auditory vestibular function in patients with Meniere’s disease(MD)and its diagnostic value.Methods A total of 102 MD patients(the MD group)and 39 healthy people(the control group)admitted to our hospital from September 2017 to September 2020 were selected.The baseline data,auditory vestibular function[minus vestibular function,speech frequency,interval period of I~V wave of auditory brainstem response(ABR)],C3,C4,IgA,IgG,IgM were compared between the two groups.The related influencing factors of MD were analyzed,and the relationship between complement,immunoglobulin and auditory vestibular function and the diagnostic value of MD were evaluated.Results The vestibular function reduction value,speech frequency,ABR I~V wave interval,C3,C4,IgA,IgG,IgM,in the MD group were greater than those in the control group,the difference was statistically significant(P<0.05).C3,C4,IgA,IgG,IgM were positively correlated with the vestibular function reduction value,speech frequency,ABR I~V wave interval in MD patients(P<0.05).C3,C4,IgA,IgG,IgM are important factors influencing the occurrence of MD(P<0.05).The area under the curve(AUC)of C3,C4,IgA,IgG,IgM combination for the diagnosis of MD is 0.945,which is the largest.Conclusion There is a good linear relationship between complement,Ig and auditory vestibular function in patients with MD.The combined detection of the two can provide an effective auxiliary means for clinical MD diagnosis and auditory vestibular function assessment.