植物CBL-CIPK信号系统的功能及其响应非生物胁迫作用机制研究进展

Functions and progress in mechanism research of CBL-CIPK signaling system in plants

植物能够快速适应非生物胁迫归功于体内复杂的响应和调控机制。钙离子(Ca^(2+))作为第二信使,负责传递外界刺激信号。钙调磷酸酶B类似蛋白(CBL)是钙离子感受器的一种,其特异性互作蛋白被称为CIPK。CBL-CIPK复合体通过蛋白磷酸化过程参与植物中大多数钙离子信号通路,在植物响应非生物胁迫的过程中发挥着重要的调控作用。本文综述了CBL-CIPK信号系统的结构性质和作用机理及其在植物应对各种非生物胁迫下的研究进展,并对CBL-CIPK信号系统的研究前景做了展望。

The complex systems and regulatory mechanisms of plants can help themselves to adapt to abiotic stress. Ca^(2+), as a second messenger, transmits signals from the external environment to cell’s interior. Calcineurin B-like proteins(CBL) is one of major Ca2+ sensors and its specific binding protein is named CBL-interacting protein kinases(CIPK). CBL-CIPK modules participate in most of calcium signaling pathways by phosphorylation and also play a critical role in plant responses to abiotic stresses. Here, we review the structural and physicochemical properties of CBL-CIPK, summarize the latest research results of CBL-CIPK and look into its prospect.