光照与哺乳动物生理稳态

Light and Mammalian Physiological Homeostasis

光作为分布最广、作用最强的环境因素之一,时刻影响着生物的生理活动,并参与多种代谢途径的调控.近年来,随着城市化进程的加速,夜间光效应已经成为机体代谢紊乱的重要诱因.另一方面,光色、光强等的合理应用也为多种疾病开拓了新的治疗手段.因此,如何更好地避免不合理光照,以减小其对人体的危害,同时,合理利用光进行疾病治疗,已成为当今社会的一个关键性挑战.本文综述了光污染所带来的危害和光在疾病治疗中的作用及其调控机制,为选择更健康的光环境和疾病辅助光疗提供了研究依据.

As one of the most widely distributed and powerful environmental factors,light constantly affects physiological activities of living systems and participates in the regulation of various metabolic pathways.In recent years,with the acceleration of urbanization,artificial light at night has become an important cause of metabolic disorders.In contrast,the reasonable application of light color and its intensity also provide new therapeutic methods for diseases.Therefore,avoiding unreasonable light and utilize beneficial light become a great challenge for the whole society.At present,several studies have confirmed that light therapy has achieved remarkable efficacy in the treatment of cancer,depression,Alzheimer’s disease and other diseases.Choosing the best lighting conditions in daily life can further improve the living environment and health of human beings.The study of light and physiological homeostasis will become the hotspot in the future.This paper reviews the roles of detrimental light pollution and beneficial light therapy in the induction and treatment of diseases,respectively,and will provide theoretical support in choosing healthier light environment and developing the light as an effective therapeutic intervention on multiple diseases.