3Acker T,Plate K H.A role for hypoxia and hypoxia-inducible transcription factors in tumor phydiology[J].MoL Med,2002,80(9):562-575.
4Semenza G L,Wang G L.A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.[J].Mol Cell Biol,1992,12(12):5447-5454.
5Unruh A,Ressed A,Mohamed H G,et al.The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy[J].Oncogene,2003,22(21):3213-3220.
6Garth P,Lynn K.Hypoxia-inducible factor-1 as a cancer drug target[J].Mol Cancer Ther,2004,3(5):647-654.
7Ratcliffe P J.New insight into an enlgmatic tumor suppressor[J].Nat Cell Biol,2003,5(1):7-8.
8Lando D,Peet D J,Whelan D A,et al.A sparagine hydroxylation of the HIF transactivation domain a hypoxic switch[J].Science,2002,295(5556):858-861.
9Carmeliet P,Dpr Y,Herber J M,et al.Role of HIF-1alpha in hypoxia medicated apoptosis,cell proliferation and tumor angiogenesis[J].Nature,1998,394(6692):485-490.
10Suzuki H,Tomida A,Tsuruo T,et al.Dephosphorylated hypoxia-inducible factor 1a as a mediator of p53 dependent aoptosis during hypoxia[J].Oncogene,2001,20(41):5779-5788.