NSE、CYFRA21-1、miR141在肺癌诊断中的价值

Value of NSE,CYFRA21-1 and miR141 in the Diagnosis of Lung Cancer

目的探讨血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、微小RNA141(miR-141)的水平变化与肺癌诊断关系。方法选取92例肺癌患者作为肺癌组、健康体检对象90例作为对照组。检测2组的血清NSE、CYFRA21-1、miR141水平;并分析不同TNM分期、淋巴结转移、病理学类型的肺癌患者血清NSE、CYFRA21-1、miR141水平差异。结果肺癌组患者的NSE、CYFRA21-1、miR141水平均显著高于对照组(P<0.05)。肺癌组患者的NSE水平在不同TNM分期、是否淋巴结转移、非小细胞肺癌与小细胞肺癌之间比较,具有统计学差异(P<0.05);肺癌组患者的CYFRA21-1水平在是否淋巴结转移的肺癌患者之间比较,具有统计学差异(P<0.05);肺癌组患者的miR141水平在不同TNM分期、是否淋巴结转移的肺癌患者之间比较,具有统计学差异(P<0.05)。血清NSE、CYFRA21-1、miR141水平在诊断肺癌中的AUC值分别为0.730、0.672、0.836;3项指标联合应用在诊断肺癌中的AUC值为0.918。结论血清NSE、CYFRA21-1、miR141水平变化与肺癌的发生发展具有一定的关系,同时三项指标联合应用对于肺癌的辅助诊断具有一定的临床价值。

Objective To investigate the relationship between serum neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1)and microRNA141(miR-141)levels and lung cancer diagnosis.Methods 92 patients with lung cancer confirmed by pathology(lung cancer group)and 90 healthy subjects(control group)were selected.Serum NSE,CYFRA21-1 and miR141 levels were detected in the 2 groups.Different TNM stages were analyzed.Serum NSE,CYFRA21-1,and miR141 levels were different in patients with lymph node metastasis and pathology.Results The levels of NSE,CYFRA21-1,and miR141 in the lung cancer group were significantly higher than those in the control group(P<0.05).The NSE levels in the lung cancer group were compared between different TNM stages,lymph node metastasis,non-small cell lung cancer,and small cell lung cancer.The difference was statistically significant(P<0.05).The CYFRA21-1 level in patients with lung cancer was statistically significant in patients with lymph node metastasis(P<0.05).The level of miR141 in lung cancer patients was different.The difference in TNM staging and lymph node metastasis was statistically significant(P<0.05).The serum ASE,CYFRA21-1,and miR141 levels in the diagnosis of lung cancer were 0.730,0.672,and 0.836,respectively.The combined use of the indicator in the diagnosis of lung cancer has an AUC value of 0.918.Conclusion The changes of serum NSE,CYFRA21-1 and miR141 levels have a certain relationship with the occurrence and development of lung cancer.At the same time,the combination of three indicators has certain clinical value for the auxiliary diagnosis of lung cancer.