心衰1号方治疗慢性心力衰竭的临床疗效及对患者左室收缩功能、 N末端脑利钠肽前体、6min步行距离及炎症指标的影响

Clinical curative effect of self-made heart failure No.1 prescription on chronic heart failure and its influences on left ventricular systolic function,N-terminal pro-brain natriuretic peptide,6-min walk distance and inflammatory factors

目的观察心衰1号方治疗慢性心力衰竭的临床疗效及对患者左室收缩功能、N末端脑利钠肽前体(NT-proBNP)、6 min步行距离及炎症指标的影响。方法将90例慢性心力衰竭患者按照随机数字表法分为2组,对照组45例予西医常规治疗,治疗组45例在对照组治疗基础上予心衰1号方治疗。2组均治疗4周。比较2组临床疗效,观察2组治疗前后左室收缩功能、NT-proBNP、6 min步行距离及炎症指标超敏C反应蛋白(hs-CRP)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)水平变化。结果治疗组总有效率91.11%(41/45),对照组总有效率75.56%(34/45),治疗组疗效优于对照组(P<0.05)。2组治疗后左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、舒张末期左心室后壁厚度(LVPWT)均较本组治疗前降低(P<0.05),左心室射血分数(LVEF)均较本组治疗前提高(P<0.05),且治疗组治疗后LVESD、LVEDD、LVPWT均低于对照组(P<0.05),LVEF高于对照组(P<0.05)。2组治疗后NT-proBNP水平均较本组治疗前降低(P<0.05),6 min步行距离较本组治疗前增加(P<0.05),且治疗组治疗后NT-proBNP水平低于对照组(P<0.05),6 min步行距离大于对照组(P<0.05)。2组治疗后hs-CRP、IL-1β、IL-6水平均较本组治疗前降低(P<0.05),且治疗组治疗后hs-CRP、IL-1β、IL-6水平均低于对照组(P<0.05)。结论心衰1号方治疗慢性心力衰竭,能改善左室收缩功能,降低NT-proBNP水平,增加6 min步行距离,降低炎症指标水平。

Objective To explore the clinical curative effect of self-made heart failure No.1 prescription on chronic heart failure(CHF)and its influences on left ventricular systolic function(LVSF),N-terminal pro-brain natriuretic peptide(NT-proBNP),6-min walk distance and inflammatory factors.Methods A total of 90 patients with CHF were divided into control group(routine western medicine)and treatment group(self-made heart failure No.1 prescription on basis of the control group)by random number table method,45 cases in each group.Both groups were treated for 4 weeks.The clinical effect,LVSF,NT-proBNP,6-min walking distance and levels of inflammatory factors were compared before and after treatment between the two groups.Results The total effective rate in the treatment group was better than that in the control group[91.11%(41/45)vs 75.56%(34/45),(P<0.05),respectively].After treatment,left ventricular end systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)and left ventricular posterior wall-depth(LVPWT)in both groups were significantly decreased(P<0.05),which were lower in treatment group than control group(P<0.05);while left ventricular ejection fraction(LVEF)in both groups was significantly increased(P<0.05),which was higher in treatment group than the control group(P<0.05);NT-proBNP level in both groups was significantly decreased(P<0.05),which was lower in treatment group than control group(P<0.05);6-min walk distance in both groups was significantly increased(P<0.05),which was higher in treatment group than control group(P<0.05);the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-1β(IL-1β)and interleukin-6(IL-6)in both groups were significantly decreased(P<0.05),which were lower in treatment group than control group(P<0.05).Conclusion The clinical effect of self-made heart failure No.1 prescription is good on chronic heart failure,which can improve left ventricular contractile function,regulate NT-proBNP level,and reduce levels of inflammatory factors.