羟基磷灰石复合材料在骨组织工程中应用的研究进展

Advances in the Application of Hydroxyapatite Composite Materials in Bone Tissue Engineering

羟基磷灰石(hydroxyapatite,HAp)是骨骼和牙齿的主要无机成分,具有生物活性和生物相容性。但HAp机械性能差、降解速度慢、功能单一,难以作为支架材料在骨组织工程中单独应用。通过将HAp与其他类型材料复合,可制备具有特定性能的复合材料,拓展其在骨组织工程中的应用。本文首先阐述了HAp材料在骨组织工程生物材料中的重要性及其优缺点,并分类回顾了HAp复合材料在骨组织工程中的研究现状;其次,针对目前HAp复合材料用于骨修复领域的研究热点,列举了代表性研究成果并进行了相应的分析讨论;最后,对HAp复合骨修复材料未来的发展前景进行了展望。

Hydroxyapatite(HAp)is the main inorganic component of the bones and teeth,and it possesses bioactivity and biocompatibility.However,due to its poor mechanical performance,slow degradation speed,and lack of diversity in its function,it is difficult to apply HAp alone as a scaffold material for bone tissue engineering.By combining HAp with other types of materials,composite materials with specific properties can be prepared,and the scopes of HAp applications can be expanded.Firstly,we elaborated on the importance,and strengths and weaknesses of HAp for bone tissue engineering biomaterials and then reviewed the research status of HAp composite materials used in bone regeneration.Secondly,about hot research topics in the field of applying HAp composite materials in bone repair,we summarized the representative findings in the field,and discussions and analysis were made accordingly.Finally,we also examined the future development prospects of HAp composite bone repair materials.