有机磷农药中毒对认知功能影响研究进展

Effect of organophosphate pesticides poisoning on cognitive impairment

有机磷农药中毒可致认知功能发生损伤,多数表现为注意力下降、警觉性降低、信息处理速度下降、记忆障碍等轻度认知功能障碍;而轻度认知功能障碍早诊断和及时干预可有较好的预后。实际临床工作中轻度认知功能障碍易长期被忽视,但对患者生活和工作可造成严重影响,甚至进展为阿尔茨海默病及帕金森病等不可逆性的神经退行性病变。因此,临床医师应提高有机磷农药中毒对患者认知功能损害的认识,尤其是针对患者发生轻度认知功能障碍时,其早发现、早诊断的意义尤为重要。

It has been suggested that organophosphate pesticides can cause cognitive impairment,most of which are presented as mild cognitive impairment such as decreased attention or vigilance,reduced information processing speed and memory impairment.An early diagnosis and timely intervention in mild cognitive impairment,which may provide a better prognosis.Mild cognitive impairment in clinical work can be easily ignored for a long time.However,it have a particularly impact on patients'life and work,and even progress to irreversible neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.Therefore,clinicians should raise the cognition of organophosphate pesticides poisoning in patients with cognitive impairment,especially for patients with mild cognitive impairment,and the significance of early detection and diagnosis of the disease is particularly important.