四神丸联合督灸治疗脾肾阳虚型腹泻型肠易激综合征疗效观察

Effect of Sishen Pill Combined with Du-Moxibustion on Diarrheal Irritable Bowel Syndrome of Spleen and Kidney Yang Deficiency Type

目的:通过与匹维溴铵片比较,探讨四神丸联合督灸对脾肾阳虚型腹泻型肠易激综合征的治疗效果。方法:采用随机数字表法将90例脾肾阳虚型腹泻型肠易激综合征患者分为治疗组(四神丸联合督灸治疗)44例和对照组(匹维溴铵片治疗)46例,对比治疗前后肠易激综合征严重程度量表(IBS-SSS)积分、中医证候积分、临床疗效及随访2个月后疗效。结果:①治疗前与治疗后比较,两组IBS-SSS积分及中医证候积分差异有统计学意义(P<0.05);治疗后治疗组患者IBS-SSS积分、各项中医证候积分及总积分均低于对照组,差异有统计学意义(P<0.05)。②治疗后,治疗组总有效率(86.36%)优于对照组(67.39%),差异有统计学意义(P<0.05);2个月后随访,治疗组总有效率(79.55%)高于对照组(56.52%),差异有统计学意义(P<0.05)。结论:四神丸联合督灸可以有效治疗脾肾阳虚型腹泻型肠易激综合征,改善中医证候,其疗效较西药稳定持久。

Objective:To investigate the therapeutic effect of Sishen Pill(四神丸)combined with Du-moxibustion on diarrheal irritable bowel syndrome(IBS)of spleen and kidney yang deficiency compared with pinaverium bromide.Methods:Using a random number table,90 patients with diarrheal IBS of spleen and kidney yang deficiency were randomly divided into treatment group(Sishen Pill combined with Du-moxibustion treatment,44 patients),and control group(pinaverium bromide tablets treatment,46 patients).Before and after treatment,the IBS symptom severity scale(IBS-SSS)scores,traditional Chinese medicine(TCM)syndrome scores,clinical efficacy,and efficacy after 2 months of follow-up were compared.Results:①In the comparison between before and after the treatment,there were differences in IBS-SSS scores and TCM syndrome scores in both groups with statistical difference(P<0.05);after the treatment,the IBS-SSS scores,TCM subset syndrome scores and total scores of patients in the treatment group were lower than those in the control group,with statistical difference(P<0.05).②After the treatment,the total effective rate of the treatment group(86.36%)was higher than that of the control group(67.39%),with statistical difference(P<0.05);2 months after follow-up,the total effective rate(79.55%)of the treatment group was higher than that in the control group,with statistical difference(P<0.05).Conclusion:Sishen Pill combined with Du-moxibustion is effective for treating diarrheal IBS of spleen and kidney yang deficiency and relieving TCM syndromes.Its curative effect is more stable and lasting compared with western medicine,and it should be promoted.