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低分子肝素治疗APS相关复发性流产研究进展

Research progress of low molecular weight heparin in the treatment of APS related recurrent abortion
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摘要 复发性流产(RSA)临床较为常见,但确切机制不明,随着流产次数增多,孕期风险越增加,夫妻评估和早期治疗RSA,对于成功妊娠非常重要.目前,临床上对于RSA的发病机制尚不完全明了,多见于遗传、免疫、感染、内分泌、解剖因素、血栓前状态以及环境因素.抗磷脂综合征(Antiphospholipid syndrome,APS)是免疫和血栓均相关RSA最常见的病因,抗磷脂抗体(APL)作用于绒毛外滋养细胞,减少其增殖侵袭能力,使子宫螺旋动脉血管重铸障碍,减少或中断母亲的血液流向胎盘,胎儿宫内缺血及营养物质供应不足,引起流产.已有文献报道,低分子肝素可用于治疗RSA并明显降低再发流产风险.本文对低分子肝素治疗APS相关复发性流产的相关文献进行了复习并作一综述,以期为临床RSA治疗提供一定参考.
出处 《首都食品与医药》 2021年第9期14-15,共2页 Capital Food Medicine
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