用双歧杆菌四联活菌片治疗肝硬化腹泻的有效性及对细胞免疫功能的影响分析

Efficacy of bifidobacterium tetralogy tablets in the treatment of cirrhotic diarrhea and its effect on cellular immune function

目的探究针对肝硬化腹泻应用双歧杆菌四联活菌片进行治疗的临床效果.方法将我院于2018年1月~2020年1月诊治的86例肝硬化腹泻患者,以对照组(n=43,常规治疗)与观察组(n=43,双歧杆菌四联活菌片治疗)的形式进行划分,对比并分析两组的免疫指标、血清肠黏膜屏障相关因子指标及临床疗效.结果观察组的CD4^(+)、CD4^(+)/CD8^(+)指标明显高于对照组(P<0.05),CD8^(+)指标则未见明显差异(P>0.05);同比对照组,观察组的D-LA、TNF-α指标明显下降,MFG-E8指标则明显提升(P<0.05);观察组的临床疗效同比对照组明显居于更高水平(P<0.05),以上差异均有统计学意义.结论针对肝硬化腹泻患者应用双歧杆菌四联活菌片进行治疗,临床效果伴随其免疫功能及肠黏膜屏障功能均得到明显改善,加速促进了患者身心健康的恢复进程,值得临床借鉴并大力推广.

objective To investigale the elinical effeet of bifidobacterium tetralogy tablets in the treatment of cirrhotic diarrhea.Methods The 86 patients with cirrhotic diarrhea diagnosed and treated in our hospital from January 2018 to January 2020 were divided into the control group(n=43,routine treatment)and the observation group(n=43,tetralogy of bifidobacterium tetralogy tablets).the immune index,serum intestinal mucosal barrier related factor index and elinical efficacy of the 1wo groups were compared and analyzed.Results The CD4^(+)、CD4^(+)/CD8^(+)index of the observation group was significantly higher than that of the control group(P<0.05),while the CD8^(+)index was not significantly different(P>0.05).The D-LA、TNF-αindex of the observation group deereased significantly compared with the control group,while the MFG-E8 index increased significantly(P<0.05).The clinical efficacy of in the observation group was higher than that in the control group(P<0.05).Conc lusion The clinical effect of bifidobacterium tetralogy tablets in patients with cirrhotic diarrhea was greatly improved with the improvement of immune function and intestinal mucosal barrier function,which accelerated the recovery reference and vigorously promote the recovery process of patients'physical and mental health.