摘要
Mammalian central nervous system(CNS)neurons lose axon regenerative ability as they mature.This failure to regenerate shows a clear contrast to a remarkable potential of axon growth during embryonic development and after an injury in the peripheral nervous system(PNS)(Hilton and Bradke,2017).The absence of regeneration in the mature CNS neurons is caused by an inhibitory influence of the environment of the injured axons and the deficit of intrinsic factors that enable regeneration in the PNS(He and Jin,2016).
基金
This work was supported by Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science 20K06880(to TN).
