摘要
Neurotrophins have been recognized for decades for their beneficial effects on growth,survival,and maintenance in the central nervous system,all of which suggest potential therapeutic utility.Although understanding and harnessing the activity of neurotrophins has proven difficult,the past several years have seen significant strides in the development of deliverable therapies that modulate neurotrophin activity(Shen et al.,2019;Yang et al.,2020;Xie et al.,2021).These recent studies have primarily focused on the multifunctional p75 neurotrophin receptor(p75NTR)which is upregulated in central nervous system disease and injury,thus offering a unique target for intervention.
基金
The present work was supported by NIH Grant R01 NS083164(to RBM).
