玉屏风颗粒联合天灸疗法治疗肺脾气虚型小儿过敏性鼻炎的临床疗效

Clinical Effect of Yupingfeng Granule Combined with Moxibustion Therapy on Children with Allergic Rhinitis

目的:观察玉屏风颗粒联合天灸疗法治疗肺脾气虚型小儿过敏性鼻炎的临床疗效及对血清IL-10、IL-4和IgE水平的影响。方法:选取2018年8月至2020年2月广州中医药大学附属中山中医院耳鼻喉科收治的肺脾气虚型过敏性鼻炎患儿80例作为研究对象,随机分为观察组和对照组,每组40例。对照组给予口服玉屏风颗粒,观察组在对照组基础上联合天灸疗法,在治疗4周后分别比较2组治疗前后鼻部不适症状、中医证候缓解情况、2组间疗效差异以及血清IL-10、IL-4和IgE水平变化。结果:治疗后观察组和对照组的鼻部症状以及肺脾气虚证候均有明显改善(P<0.05),且观察组总有效率显著优于对照组(P<0.05);治疗后2组IL-10、IL-4和IgE水平均降低,观察组明显低于对照组(P<0.05)。结论:玉屏风颗粒联合天灸疗法治疗肺脾气虚型小儿过敏性鼻炎疗效确切,且优于单独应用玉屏风颗粒者。

Objective:To observe the clinical effect of Yupingfeng granules combined with medicinal vesiculation on allergic rhinitis in children with deficiency of lung-spleen qi,and the effect on serum IL-10,IL-4 and IgE levels.Methods:A total of 80 child patients with allergic rhinitis caused by deficiency of lung-spleen qi admitted in the Department of Otolaryngology,Zhongshan Hospital of Traditional Chinese Medicine(TCM),Guangzhou University of TCM from August 2018 to February 2020 were chosen and randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given Yupingfeng Granules,and the observation group was treated with medicinal vesiculation on the basis of the control group.After treatment of 4 weeks,the symptoms of nasal discomfort,the remission of TCM syndrome,the difference of clinical effect between the 2 groups as well as the levels of IL-10,IL-4 and IgE were compared.Results:After treatment,the nasal symptoms and deficiency of lung-spleen qi in the 2 groups were significantly improved(P<0.05),and the effect of the observation group was significantly better than control group(P<0.05).IL-10,IL-4 and IgE in the 2 groups were significantly reduced after treatment,and the observation group was significantly lower than the control group(P<0.05).Conclusion:The efficacy of Yupingfeng Granules combined with medicinal vesiculation on allergic rhinitis in child patients with deficiency of lung-spleen qi is better than that of Yupingfeng Granules alone.