2019年濮阳市疑似预防接种异常反应监测分析

Surveillance and analysis of adverse events following immunization in Puyang city, 2019

目的分析2019年河南省濮阳市疑似预防接种异常反应(adverse event following immunization,AEFI)监测数据,评价AEFI系统运转情况。方法从中国免疫规划信息管理系统AEFI监测管理系统中收集2019年濮阳市AEFI监测数据,开展描述流行病学分析。结果 2019年濮阳市AEFI共报告896例、发生率53.42/10万,各项监测指标均达到要求,其中NIP疫苗报告发生率58.03/10万,非NIP疫苗报告发生率42.56/10万;一般反应882例(98.44%)、报告发生率52.89/10万,异常反应11例(1.23%)、报告发生率0.66/10万,偶合症3例(0.33%)、报告发生率0.18/10万;男女性别比为1.43∶1;1岁及以下婴儿共612例、占68.30%;全年每个月均有病例报告,7—9月报告数高于其他月;894例非严重AEFI全部痊愈,2例严重AEFI,其中1例痊愈、1例仍在治疗;疫苗接种到AEFI发生间隔时间0 d~共847例、占94.53%。结论濮阳市AEFI监测系统运转良好;应加强基层工作人员培训,提高严重AEFI监测敏感性,并做好接种后30 min内的留观工作。

Objective To analyze the surveillance data of suspected adverse event following immunization(AEFI) and evaluate the operating condition of AEFI system in Puyang city, 2019. Methods The surveillance data of AEFI in Puyang city, 2019 were collected from the AEFI surveillance management system of Chinese information management system for immunization planning and analyzed with descriptive epidemiology. Results A total of 896 cases of AEFI were reported in Puyang, 2019, with a reported incidence of 53.42/100 000. All indexes met the requirements of the surveillance. The reported incidence of AEFI was 58.03/100 000 of NIP vaccine and 42.56/100 000 of non-NIP vaccine. There were 882(98.44%) cases of general reaction with reported incidence of 52.89/100 000, 11(1.23%) cases of abnormal reaction with reported incidence of 0.66/100 000, and 3(0.33%) cases of coincident reaction with 0.18/100 000. The ratio of the male to the female was 1.43∶1. Totally 612 cases were infants at age of 1 year and younger, accounting for 68.30%. There were cases reported in every month all the year, and the number of cases reported during July to September was higher than that in other months. All of894 cases of non-serious AEFI were cured. Out of the 2 cases of serious AEFI, 1 case was cured and another 1 was still under treatment. There were 847 cases with 0-1 day of interval time from the vaccination to occurrence of AEFI, accounting for94.53%. Conclusions The surveillance system of AEFI works well in Puyang. The training of staff at the grass-roots level should be strengthened to improve the sensitivity of serious AEFI in the surveillance, and observe within 30 minutes after the vaccination.