细胞衰老在特发性肺间质纤维化中作用的最新进展

The latest research progress on the role of cell senescence in idiopathic pulmonary interstitial fibrosis

特发性肺间质纤维化(IPF)是一种慢性、进行性和以肺纤维化为主要特征的致命性疾病,属于间质性肺疾病的一种。IPF的病因至今未明,可在全球范围内发病,发病人群主要涉及到老年人,因其发病机制尚未完全阐明,临床上缺乏彻底治愈的有效治疗措施,预后极差,严重威胁人类生命健康。IPF是一种与衰老相关的慢性肺部疾病,本文主要介绍与细胞衰老相关的线粒体异常、第10号染色体缺失的磷酸酶和张力同源基因(gene of phosphate and tension homology deleted on chromsome ten,PTEN)表达缺失、自噬不足等方面的研究进展在IPF发病中的作用,以期为今后的防治工作提供新的思路和方向。

The diopathic pulmonary interstitial fibrosis(IPF)is a chronic,progressive and fatal disease characterized by pulmonary fibrosis,which belongs to one kind of interstitial lung diseases.The etiology of IPF is still unknown,which can occur all over the world.The disease mainly involves the elderly,because its pathogenesis has not been fully clarified,there are no effective treatment measures in clinical practice,and the prognosis of patients is very poor,which severely threaten the human life and health.IPF is a chronic lung disease related to senescence.This article mainly introduces the role of mitochondrial abnormalities related to cell senescence,loss of expression of phosphatase and tension homologous gene(gene of phosphate and tension homology deleted on chromosome ten,PTEN)deleted on chromosome 10,and autophagy deficiency in the pathogenesis of IPF,in order to provide new ideas and directions for prevention and treatment of the disease in the future.