甲磺酸倍他司汀片联合手法复位治疗良性阵发性位置性眩晕的疗效

The clinical effects of betahistine mesilate tablets combined with manual reduction in treatment of benign paroxysmal positional vertigo

目的探讨甲磺酸倍他司汀片联合手法复位治疗后半规管良性阵发性位置性眩晕(BPPV)的临床效果。方法选择2018年10月至2019年10月就诊的150例后半规管BPPV患者,随机分为对照组和观察组,每组75例。对照组采用传统的Epley手法复位治疗,观察组在对照组Epley手法复位的基础上联合甲磺酸倍他司汀片治疗。比较2组临床疗效、前庭症状指数、生活质量和复发率情况。结果观察组治疗总有效率为58.67%高于对照组的44.00%,差异有统计学意义(P<0.05);观察组前庭症状指数评分小于对照组,差异有统计学意义(P<0.05);治疗前2组DHI各项评分差异无统计学意义(P>0.05),治疗后2周及1个月均较治疗前下降(P<0.05),且观察组下降更多(P<0.05);观察组复发率为6.67%低于对照组的14.67%,但差异无统计学意义(P=0.11)。结论甲磺酸倍他司汀片联合手法复位治疗后半规管BPPV临床效果优于单纯手法复位,可明显减轻症状,降低复发率,提高生活质量。

Objective To investigate the clinical effects of betahistine mesilate tablets combined with manual reduction in treatment of benign paroxysmal positional vertigo(BPPV).Methods A total of 150 patients with posterior semicircular canal BPPV who were treated in our hospital from October 2018 to October 2019 were enrolled in the study,who were randomly divided into control group and observation group,with 75 cases in each group.The patients in control group were treated by traditional Epley manual reduction,however,the patients in observation group,on the basis of control group,were treated by oral betrelastine mesylate tablets.The clinical efficacy,vestibular symptom index,life quality and relapse rate were observed and compared between the two groups.Results The total effective rate in observation group was 58.67%,which was significantly higher than that(44.00%)in control group(P<0.05).After treatment,the vestibular symptom index scores in observation group were significantly lower than those in control group(P<0.01).Before treatment there were no significant differences in DHI scores between the two groups(P>0.05),which at 2w and 1m after treatment in both groups were significantly decreased,moreover,the decrease degree in observation group was more significant than that in control group(P<0.05).In addition the relapse rate in observation group was 6.67%,which was lower than that(14.67%)in control group,but the difference was not statistically significant(P>0.05).Conclusion The clinical effects of betahistine mesilate tablets combined with manual reduction in treatment of posterior semicircular canal BPPV are superior to those by simple manual reduction,which can significantly relieve clinical symptoms and relapse rate.