摘要
脂肪间充质干细胞(ADSC)外泌体作为细胞间交流的重要手段,在创面修复与组织再生方面的作用受到越来越多的关注。本文通过阐述ADSC外泌体在创面愈合中对成纤维细胞(Fb)、内皮细胞、角质形成细胞(KC)和巨噬细胞调控作用的研究进展,以期为创面修复提供新的思路。
Exosomes from adipose derived mesenchymal stem cell(ADSC),a crucial means of intercellular communication,have been widely applied in wound healing and tissue regeneration in recent years.This article mainly describes the research progress of regulative effects of ADSC exosomes on fibroblasts,endothelial cells,keratinocytes,and macrophages in the process of wound healing,in order to provide novel insight to wound healing.
作者
沈括
张锦鑫
王洪涛
胡大海
Shen Kuo;Zhang Jinxin;Wang Hongtao;Hu Dahai(Department of Burns and Cutaneous Surgery,Burn Center of PLA,First Affiliated Hospital,Air Force Medical University,Xi′an 710032,China;Department of Emergency,First Affiliated Hospital,Air Force Medical University,Xi′an 710032,China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2021年第3期260-264,共5页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
国家自然科学基金重点项目(81530064)
国家自然科学基金面上项目(81772071,81971835)。
关键词
间质干细胞
外泌体
伤口愈合
Mesenchymal stem cells
Exosomes
Wound healing
