湖北省级医院单中心连续10年淋巴瘤临床流行病学特点分析

Epidemiological characteristics of lymphoma in a single center of a provincial hospital in Hubei province for 10 consecutive years

目的通过分析武汉大学人民医院连续10年淋巴瘤患者的临床和病理资料,探讨淋巴瘤流行病学特点。方法回顾性分析2009-01-01-2018-12-31武汉大学人民医院单中心淋巴瘤患者发病年龄、性别、病理类型及首发部位等资料,以及连续10年淋巴瘤年诊断病例数量变化趋势。结果1871例患者男1100例(58.8%),女771例(41.2%),男女比例为1.42∶1。年龄2~98岁,中位年龄53岁,发病高峰年龄50~69岁(51.1%)。病理类型:非霍奇金淋巴瘤(NHL)占90.8%(1698/1871),其中B细胞非霍奇金淋巴瘤(B-NHL)占67.6%(1264/1871),T/NK细胞非霍奇金淋巴瘤(T/NK-NHL)占23.2%(434/1871);霍奇金淋巴瘤(HL)占5.45%(102/1871),不可分类淋巴瘤占3.75%(71/1871)。弥漫性大B细胞淋巴瘤(DLBCL)是NHL最常见亚型。首发部位:淋巴结内占45.0%(842/1871),其中浅表淋巴结肿大为首发占79.9%(673/842);结外起病占55.0%(1029/1871),常见部位为消化道、韦氏环及鼻腔。淋巴瘤患者诊断病例数由2009年74例增长到2018年403例,年平均增长20.7%,趋势性检验差异有统计学意义,Z=3.58,P=0.0003。结论湖北地区淋巴瘤流行病学特点与欧美国家明显不同,与国内其他地区也有差异;10年来诊断病例数呈逐年升高趋势与我国淋巴瘤发病增长趋势一致。

Objective To analyze the clinical and pathological data of lymphoma in Renmin Hospital of Wuhan University for 10 consecutive years and to investigate the epidemiological characteristics of lymphoma in this area.Methods The age of onset,sex,pathological type and initial site of lymphoma patients in single center of Hubei provincial hospital on January 1.2009 and December 31.2018 were retrospectively analyzed,as well as the trend of the number of lymphoma patients diagnosed annually for 10 consecutive years.Results Totally 1100 male cases(58.8%)and 771 female cases(41.2%)were included in 1871 patients,the ratio of men to women was 1.42∶1.age range of 2-98 years,with a median age of 53 years,with a peak age of 50-69 years accounting for 51.1%.Pathological types accounted for 90.8%(1698/1871)in Non-Hodgkin Lymphoma(NHL),of which B cell NHL(B-NHL)67.6%(1264/1871)and T and NK cell NHL(T/NK-NHL)23.2%(434/1871);5.45%(102/1871)in Hodgkin Lymphoma(HL)and 3.75%(71/1871)in unclassified;Diffuse large b cell lymphoma(DLBCL)was the most common subtype.Lymph nodes at the initial site accounted for 45.0%(842/1871),among which,superficial lymphadenopathy was 79.9%(673/842),the extranodal onset was 55.0%(1029/1871),the common sites were digestive tract,Wechsler’s ring and nasal cavity.The number of diagnosed cases increased from 74 cases in 2009 to 403 cases in 2018,an average annual increase of 20.7%,and the difference in trend test was statistically significant(Z=3.58,P=0.0003).Conclusion The epidemiological characteristics of lymphoma in Hubei are obviously different from those in Europe and America,and also different from those in other parts of China,and the number of diagnosed cases has been increasing for 10 consecutive years,which is consistent with the increasing trend of lymphoma incidence in China.