淋病奈瑟菌耐药机制研究进展

Advances in research on the resistance mechanism of Neisseria gonorrhoeae

淋病是由淋病奈瑟菌(淋球菌)感染引起的一种性传播疾病,其流行和蔓延已成为全球公共卫生事业巨大的负担.抗菌药物治疗是目前淋病防治的主要方式,但随着抗菌药物在临床上的广泛应用,淋球菌的耐药性问题日益严重.深入探究淋球菌的耐药机制,对完善其耐药监测体系和调整临床用药方案均有重要意义.本文在回顾近几年淋球菌耐药机制相关研究的基础上,就临床上几种常见抗菌药物耐药机制的最新研究进展进行了综述,旨在为我国淋病防治策略的制定提供依据.

Gonorrhea is a sexually transmitted disease caused by Neisseria gonorrhoeae infection. Its prevalence and spread have become a huge burden on global public health. Antimicrobial therapy is currently the main method for the prevention and treatment of gonorrhea. However, with the widespread use of antibacterial agents in clinical practice, the resistance of N. gonorrhoeae has become an increasingly serious problem. Exploration of the resistance mechanism of N. gonorrhoeae is essential for improving its resistance monitoring system and adjusting the antimicrobial treatment regimens. We reviewed the recent advances in research on the resistance mechanism of N. gonorrhoeae, aiming to provide reference for the prevention and treatment of gonorrhea in China.