氨溴索联合抗生素治疗慢性支气管炎急性加重期的临床研究

Clinical Study of Ambroxol Combined with Antibiotics in the Treatment of Acute Exacerbation of Chronic Bronchitis

目的:观察氨溴索联合抗生素治疗慢性支气管炎急性加重期的临床研究。方法:笔者所在医院2020年1-10月收治慢性支气管炎急性加重期的患者40例采取氨溴索联合抗生素治疗为观察组,并选取同期仅接受抗生素治疗的40例患者设为对照组。比较两组患者临床症状消失时间,治疗前、后肺功能与炎性指标,临床疗效与安全性。结果:观察组咳嗽、咳痰、喘息、呼吸困难的临床症状消失时间均早于对照组,差异均有统计学意义(P<0.05)。两组治疗前肺功能与炎性指标相比,差异均无统计意义(P>0.05)。治疗后肺功能指标升高,血清炎性指标水平降低,且观察组优于对照组,差异均有统计意义(P<0.05)。观察组患者治疗总有效率(95.00%)高于对照组(75.00%),且观察组的并发症发生率(2.50%)低于对照组(17.50%),差异均有统计学意义(P<0.05)。结论:在慢性支气管炎急性加重期患者的治疗中,实施以氨溴索联合抗生素治疗,可较为明显的缩短患者临床症状消失的时间,改善治疗后肺功能,降低机体内炎性指标,提升临床治疗效果,减少并发症发生。

Objective:To observe the clinical research analysis of Ambroxol combined with antibiotics in the treatment of acute exacerbation of chronic bronchitis.Method:A total of 40 patients in the acute exacerbation of chronic bronchitis who were admitted to our hospital from January to October 2020 were treated with Ambroxol combined with antibiotics and set up as the observation group.Other 40 patients who were treated with only antibiotics during the same period were selected as the control group.Compared the time of disappearance of clinical symptoms between the two groups,lung function and inflammatory indexes before and after treatment,clinical efficacy and safety in the two groups.Result:The disappearance time of clinical symptoms of cough,sputum,wheezing and dyspnea in the observation group were earlier than those of the control group,and the differences were statistically significant (P<0.05).There were no significant differences in lung function and inflammatory indexes between the two groups before treatment (P>0.05).After treatment,the pulmonary function indexes increased and the serum inflammatory index levels decreased,and the observation group was better than the control group,the differences were significant (P<0.05).The total effective rate of treatment in the observation group (95.00%) was higher than that of the control group (75.00%),and the complications in the observation group (2.50%) were lower than that of the control group (17.50%).The differences were significant (P<0.05).Conclusion:In the treatment of patients with acute exacerbation of chronic bronchitis,the implementation of Ambroxol combined with antibiotics can significantly shorten the time for patients to disappear from clinical symptoms,improve lung function indicators after treatment,reduce inflammatory indicators in the body,and improve the clinical treatment effect,reduces the occurrence of complications and the effect is ideal.