纳米材料改善肿瘤缺氧增强声动力疗效的研究进展

Research progress of nanomaterials to enhance the efficacy of sonodynamic treatment by relieving tumor hypoxia

声动力疗法(SDT)是一种由光动力学疗法(PDT)发展而来的新兴、无创的治疗方法,由于具有更深的辐射距离且无光毒性特点逐渐替代传统的PDT。氧气是SDT发挥抗肿瘤过程的重要因素,但是肿瘤长期处于缺氧微环境中,极大限制SDT的疗效。纳米材料可灵活应对肿瘤微环境这一缺氧特点,提供有效的供氧策略增强SDT抗肿瘤效应。当前对于纳米材料改善缺氧来增强SDT抗肿瘤疗效方面的综述较少,本文就SDT的作用机制,以及纳米材料改善肿瘤缺氧从而增强SDT的研究进展进行综述。

Sonodynamic treatment(SDT) is a new non-invasive treatment method developed from photodynamic treatment(PDT).Due to the characteristics of deeper radiation distance and no phototoxicity,it gradually replaces traditional PDT.Oxygen is an important part of the SDT in the anti-tumor process,but the tumor has been in a hypoxic microenvironment for a long time,which greatly limits the efficacy of SDT.Nanomaterials can flexibly respond to the hypoxic characteristics of the tumor microenvironment and provide effective oxygen supply strategies to enhance the anti-tumor effect of SDT.At present,there are few reviews on nanomaterials to improve the antitumor efficacy of SDT by improving hypoxia.This review briefly introduces the mechanism of SDT and mainly discusses the progress of nanomaterials in improving tumor hypoxia and enhancing the sonodynamic efficacy.