消化内镜止血治疗对非静脉曲张性上消化道出血患者再出血及炎性反应的影响

Influence of Endoscopic Hemostasis on Rebleeding and Inflammatory Reactions in Patients with Non Variceal Upper Gastrointestinal Bleeding

目的探讨消化内镜止血治疗对非静脉曲张性上消化道出血患者再出血和炎性反应的影响。方法将2017年1月至2020年6月我院收治的116例非静脉曲张性上消化道出血患者随机分为研究组(n=58)和参照组(n=58)。参照组给予消化内镜下药物治疗,研究组给予消化内镜下药物联合钛夹止血治疗。比较两组的总出血量、再出血率、炎性反应指标(IL-6、CRP、TNF-α)及应激反应指标(GH、Cor、ADH)。结果研究组的总出血量、再出血率低于参照组(P<0.05)。治疗后,研究组的IL-6、CRP、TNF-α、GH、Cor、ADH水平均低于参照组(P<0.05)。结论消化内镜下药物联合钛夹止血治疗非静脉曲张性上消化道出血患者可有效减少出血量,控制再出血,并有助于减轻机体炎性反应与应激反应。

Objective To explore the influence of endoscopic hemostasis on rebleeding and inflammatory reactions in patients with non variceal upper gastrointestinal bleeding.Methods 116 patients with non variceal upper gastrointestinal bleeding admitted to our hospital from January 2017 to June 2020 were randomly divided into study group(n=58)and reference group(n=58).The reference group was given endoscopic drug treatment,and the study group was given endoscopic drug combined with titanium clip hemostasis.The total blood loss,rebleeding rate and inflammatory reaction indicators(IL-6,CRP,TNF-α)and stress response indicators(GH,Cor,ADH)were compared between the two groups.Results The total blood loss and rebleeding rate of the study group were lower than those of the reference group(P<0.05).After treatment,the levels of IL-6,CRP,TNF-α,GH,Cor and ADH in the study group were lower than those in the reference group(P<0.05).Conclusions Endoscopic drug combined with titanium clip hemostasis in the treatment of patients with non variceal upper gastrointestinal bleeding can effectively reduce the blood loss,control the rebleeding,and help to reduce the body inflammatory reactions and stress response.