肝动脉化疗栓塞术介入治疗原发性肝癌的预后影响因素分析

Analysis on Influencing Factors of the Prognosis of Transarterial Chemoembolization in the Interventional Therapy of Primary Liver Cancer

目的分析影响肝动脉化疗栓塞术(TACE)介入治疗原发性肝癌(PLC)预后的相关因素。方法选取2017年4月至2019年5月在我院行TACE介入治疗的PLC患者88例,术后随访1年,统计患者预后情况,并收集患者基线资料,包括年龄、病理学类型、TNM分期、门静脉栓子、肝内转移、甲胎蛋白(AFP)水平等,分析影响PLC预后的相关因素。结果随访1年,88例患者中病死15例,病死率为17.05%;经单因素与多因素分析显示,AFP水平高、肝内转移、有门静脉栓子是影响TACE介入治疗PLC预后的危险因素(OR>1,P<0.05)。结论AFP水平高、肝内转移、有门静脉栓子均为影响TACE介入治疗PLC预后的危险因素,临床需对上述因素进行合理干预,以有效改善患者预后。

Objective To analyze the related factors that affecting the prognosis of transarterial chemoembolization(TACE)in the interventional therapy of primary liver cancer(PLC).Methods 88 PLC patients with TACE interventional therapy in our hospital from April 2017 to May 2019 were selected.They were followed up for 1 year after surgery,the prognosis of patients were counted,and their baseline data were collected,including age,pathological type,TNM stage,portal vein thrombosis,intrahepatic metastasis and alpha fetoprotein(AFP)level.The related factors that affecting the PLC prognosis were analyzed.Results After 1 year of follow-up,among 88 cases of patients,15 cases died of disease,with mortality rate of 17.05%.Univariate and multivariate analysis showed that high AFP level,intrahepatic metastasis and portal vein thrombosis were the risk factors that affecting the prognosis of TACE interventional therapy for PLC(OR>1,P<0.05).Conclusions High AFP level,intrahepatic metastasis and portal vein thrombosis are the risk factors that affecting the PLC prognosis after TACE interventional therapy.It is necessary to carry out reasonable intervention on the above factors in order to effectively improve the prognosis of patients.