血Preβ1-HDL对冠心病患者冠脉病变严重程度预测价值的相关性

Correlation Study of Blood Preβ1-HDL Predictive Value of Coronary Artery Disease Severity in Patients with Coronary Heart Disease

目的探讨preβ1-HDL对冠心病患者冠脉病变严重程度预测价值的相关性。方法在昆明市第一人民医院行冠脉介入诊断和\或治疗的90例患者,顺序入组,其中冠心病患者70例(其中冠心病单支病变15例,冠心病多支病变55例),冠脉正常患者20例。收集各组临床基线资料。采用ELISA法测定血preβ1-HDL浓度。用SPSS进行统计分析。结果在不同冠脉病变严重程度患者中血preβ1-HDL水平,差异有统计学意义(P<0.05)。Preβ1-HDL浓度与冠脉Gensini评分呈正相关(P<0.000),相关性为(r=0.782)。Preβ1-HDL浓度与cTnT呈正相关(P<0.000),相关性为(r=0.421)。血Preβ1-HDL的ROC曲线下面积(AUC)为0.993,诊断界值为3.66,敏感度和特异度分别为100%和94.7%。结论初步发现血Preβ1-HDL浓度可以作为预测冠心病冠脉病变严重程度的新指标。

Objective To investigate the correlation between Preβ1-HDL and the predictive value of coronary artery disease severity in patients with coronary heart disease.Methods In this study,90 patients undergoing coronary intervention diagnosis and/or treatment in our hospital were enrolled sequentially.Among them,there were 70 patients with coronary artery disease(including 15 patients with single coronary artery disease,55 patients with multiple coronary artery disease)and 20 patients with normal coronary artery disease.Clinical baseline data of each group were collected.Blood preβ1-HDL concentration was determined by ELISA.SPSS was used for statistical analysis.Results The results of this study showed that blood preβ1-HDL levels in patients with different severity of coronary artery disease had the statistically significant differences(P<0.05).Preβ1-HDL concentration was positively correlated with coronary Gensini score(P<0.000),and the correlation was(r=0.782).Preβ1-HDL concentration was positively correlated with cTnT(P<0.000),and the correlation was(r=0.421).The area under ROC curve(AUC)of blood Preβ1-HDL was 0.993,the diagnostic threshold was 3.66,and the sensitivity and specificity were 100%and 94.7%,respectively.Conclusion Blood Preβ1-HDL concentration has been found to be a new indicator to predict the severity of coronary artery disease.