摘要
肢端肥大症过度分泌的生长激素产生胰岛素抵抗,易合并糖尿病。其主要机制是通过生长激素受体发挥一系列作用,影响胰岛素受体和其底物磷酸化水平、磷脂酰肌醇3激酶的调节亚基p85α水平、葡萄糖转运水平及11β-羟基类固醇脱氢酶活性,从而造成血糖代谢紊乱,引起糖尿病发生。
Hypersecretion of GH in acromegaly produces the insulin resistance and is prone to diabetes mellitus.The main mechanism is that the insulin receptor and its substrate phosphorylation level,phosphatidylinositol 3 kinase regulatory subunit P85 level,glucose transport level and 11β-Hydroxysteroid Dehydrogenaseactivity play a series of roles through the growth hormone receptor,resulting in glucose metabolism disorder.
作者
钟俊
付景云
ZHONG Jun;FU Jing-yun(Dept.of Endocrinology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2021年第5期159-164,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81860265)
云南省高层次卫生健康技术人才基金资助项目(D-2018035)。
关键词
肢端肥大症
生长激素
糖尿病
Acromegaly
Growth hormone
Diabetes mellitus