肢端肥大症并发糖尿病的发病机制

The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus

肢端肥大症过度分泌的生长激素产生胰岛素抵抗,易合并糖尿病。其主要机制是通过生长激素受体发挥一系列作用,影响胰岛素受体和其底物磷酸化水平、磷脂酰肌醇3激酶的调节亚基p85α水平、葡萄糖转运水平及11β-羟基类固醇脱氢酶活性,从而造成血糖代谢紊乱,引起糖尿病发生。

Hypersecretion of GH in acromegaly produces the insulin resistance and is prone to diabetes mellitus.The main mechanism is that the insulin receptor and its substrate phosphorylation level,phosphatidylinositol 3 kinase regulatory subunit P85 level,glucose transport level and 11β-Hydroxysteroid Dehydrogenaseactivity play a series of roles through the growth hormone receptor,resulting in glucose metabolism disorder.