结肠镜下内痔聚桂醇硬化剂注射治疗对内痔患者临床效果、细胞免疫状态及不良反应的影响

Effect of Lauryl Alcohol Sclerotherapy on Clinical Efficacy,Cellular Immune Status and Adverse Reactions in Patients with Internal Hemorrhoids under Colonoscopy

目的:探讨采用聚桂醇硬化剂注射治疗内痔,对患者临床疗效、细胞免疫指标和不良反应的具体影响。方法:选取笔者所在医院于2019年1月-2020年1月临床收治的内痔患者80例为研究对象,随机将患者分成研究组和对照组,每组患者40例。对照组给予传统手术方法进行治疗,研究组给予结肠镜下聚桂醇硬化剂注射治疗。对两组患者临床综合疗效、细胞免疫指标、临床治疗指标和不良反应发生率进行观察和比较。结果:治疗后,研究组患者的总有效率为97.50%,高于对照组的90.00%,但组间差异无统计学意义(P>0.05);治疗3 d及7 d两组的细胞免疫指标均显著优于治疗前,且研究组的细胞免疫指标均显著优于对照组,差异有统计学意义(P<0.05);研究组患者的手术时间和住院时间短于对照组(P<0.05),研究组患者的术中出血量和治疗费用少于对照组(P<0.05),研究组患者治疗后1年不良反应发生率为5.00%,低于对照组的20.00%,组间比较差异有统计学意义(P<0.05)。结论:采用结肠镜下内痔聚桂醇硬化剂注射治疗方法能够改善内痔患者术后细胞免疫状态,促进患者术后康复,降低术后不良反应发生率,具有较好的临床应用价值。

Objective:To investigate the effect of Lauryl Alcohol Sclerosing agent injection on the clinical efficacy,cellular immune indexes and adverse reactions of patients with internal hemorrhoids.Method:From January 2019 to January 2020,80 cases of internal hemorrhoids patients in our hospital were selected as the research objects,and the patients were randomly divided into study group and control group,40 cases in each group.The control group was treated with traditional surgical methods,and the study group was treated with lauryl alcohol sclerotherapy under colonoscopy.The clinical comprehensive efficacy,cellular immune index,clinical treatment index and incidence of adverse reactions were observed and compared between the two groups.Result:After treatment,the total effective rate of the study group was 97.50%,higher than 90.00% of the control group,but there was no significant difference between the two groups (P>0.05).At 3,7 day,the cellular immune indexes of the two groups were significantly better than those before treatment,and the cellular immune indexes of the study group were significantly better than those of the control group,the difference was statistically significant (P<0.05).The operation time and hospital stays of the study group were significantly shorter than those of the control group (P<0.05).Intraoperative blood loss and treatment expense were less than those of the control group (P<0.05).The incidence of adverse reactions was 5.00% in the study group,lower than 20.00% of the control group,and the difference between the two groups was statistically significant (P<0.05).Conclusion:The injection of Lauryl Alcohol Sclerotherapy for internal hemorrhoids under colonoscopy can improve the cellular immune status of patients with internal hemorrhoids,promote the recovery of patients after operation,and reduce the incidence of adverse reactions,which has good clinical application value.