β_(2)受体激动剂与抗胆碱药联用在慢阻肺患者中的应用

Application of β_(2) Receptor Agonist Combined with Anticholinergic Drugs in COPD Patients

目的:探讨β_(2)受体激动剂与抗胆碱药联用对慢性阻塞性肺疾病(慢阻肺)的治疗效果。方法:选取2019年9月-2020年11月本院呼吸内科的接受治疗的50例慢阻肺患者。采用随机抽签法分为对照组和观察组,各25例。对照组采用β_(2)受体激动剂沙丁胺醇气雾剂治疗,观察组联合使用抗胆碱药异丙托溴铵气雾剂。比较两组临床疗效、用药前后肺功能、血气指标和药物不良反应。结果:观察组治疗总有效率为96.00%,高于对照组的64.00%(P<0.05)。观察组不良反应发生率为4.00%,低于对照组的32.00%(P<0.05)。用药前,两组肺功能和血气指标比较差异无统计学意义(P>0.05);用药后,观察组肺活量为(2.36±0.21)L,用力肺活量为(2.09±0.36)L,最大呼气流量为(458.72±24.32)L/min,动脉氧分压为(62.14±4.36)mm Hg,血氧饱和度为(90.12±8.78)%,高于对照组的(1.98±0.32)L、(1.78±0.27)L、(420.56±18.45)L、(56.54±4.18)mm Hg和(81.24±9.32)%;观察组二氧化碳分压为(47.24±3.45)mm Hg,低于对照组的(55.21±4.12)mm Hg,差异均有统计学意义(P<0.05)。结论:在慢阻肺治疗中联合使用β_(2)受体激动剂和抗胆碱药,效果明显,可改善患者肺功能和血气指标,也可减少单一药物治疗所致不良反应,可推广。

Objective:To investigate the therapeutic effect of β_(2) receptor agonist combined with anticholinergic drugs on chronic obstructive pulmonary disease(COPD).Method:Fifty patients with COPD who received treatment in the Department of Respiratory Medicine of our hospital from September 2019 to November 2020 were randomly divided into control group and observation group by drawing lot,with 25 cases in each group.The control group was treated with the β_(2) agonist Salbutamol Aerosol,while the observation group was combined with the anticholinergic drug Ipratropium Bromide Aerosol.The clinical efficacy and pulmonary function before and after treatment,blood gas indexes and adverse drug reactions were compared between the two groups.Result:The total effective rate of the observation group was 96.00%,which was higher than 64.00%of the control group(P<0.05),and the adverse reaction rate(4.00%)was lower than 32.00%of the control group(P<0.05).Before medication,there were no differences in lung function and blood gas indexes between the two groups(P>0.05);after medication,the vital capacity of the observation group was(2.36±0.21)L,and the forced vital capacity was(2.09±0.36)L,the maximum expiratory flow was(458.72±24.32)L/min,arterial oxygen partial pressure was(62.14±4.36)mm Hg,blood oxygen saturation was(90.12±8.78)%,which were higher than[(1.98±0.32)L,(1.78±0.27)L,(420.56±18.45)L,(56.54±4.18)mm Hg and(81.24±9.32)%of the control group;the partial pressure of carbon dioxide of the observation group was(47.24±3.45)mm Hg,which was lower than(55.21±4.12)mm Hg in the control group,the differences were statistically significant(P<0.05).Conclusion:The combined use of β_(2) receptor agonist and anticholinergic drugs in COPD treatment has obvious effect,which can improve lung function and blood gas index of patients,and reduce adverse reactions caused by single drug treatment,which can be popularized.