TGF-β/Smad信号通路在糖尿病性心肌病中的致纤维化作用

Function of TGF-β/Smad Signal Path on Fibrosis of Diabetic Cardiomyopathy

概述糖尿病性心肌病(DCM)及其病理改变,简述了转化生长因子-β,回顾TGF-β/Smad信号通路与心肌纤维化,探讨中药对TGF-β/Smad信号通路的影响,深入研究TGF-β/Smad信号通路致纤维化的复杂作用机制,展望高选择性抑制剂在未来的应用前景。

The research summarizes DCM and its pathologic change,describes TGF-β,reviews TGF-β/Smad signal path and myocardial fibrosis,explores the influence of traditional Chinese medicine on TGF-β/Smad signal path,deeply researches the complex function mechanism of TGF-β/Smad signal path fibrosis,and outlooks the application prospect of high selectivity inhibitor.