非小细胞肺癌免疫治疗的研究

Research on Immunotherapy of Non-small Cell Lung Cancer

肺癌是临床常见的恶性肿瘤,且多数患者就诊已失去手术治疗时机,临床多采用化疗、放疗、靶向治疗等联合治疗,但是临床治疗效果不佳,5年生存率仍然较低,严重威胁患者的生命安全。随着现代医学水平的发展,免疫学得到快速进展,尤其是免疫学治疗恶性肿瘤取得一定的临床效果,备受临床关注和重视。本文就免疫系统与肺癌关系、肿瘤疫苗以及免疫检查点抑制剂临床进展作一综述,以期为非小细胞肺癌的临床治疗提供一定的理论依据。

Lung cancer is a common malignant tumor in the clinic,and most patients have lost the opportunity for surgical treatment.Clinically,combined treatments such as chemotherapy,radiotherapy,and targeted therapy are often used.However,the clinical treatment effect is not good,and the 5-year survival rate is still low,which seriously threatens the life safety of patients.With the development of modern medicine,immunology has made rapid progress.In particular,immunology has achieved certain clinical effects in the treatment of malignant tumors,which has attracted clinical attention and attention.This article reviews the relationship between the immune system and lung cancer,the clinical progress of tumor vaccines and immune checkpoint inhibitors,in order to provide a theoretical basis for the clinical treatment of non-small cell lung cancer.