无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的 临床效果

Clinical effect of non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure

目的探讨无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的临床效果。方法选择2019年11月至2021年3月我院收治的60例COPD合并呼吸衰竭患者作为研究对象,根据就诊顺序将其分为对照组(n=30)与试验组(n=30)。对照组给予常规对症治疗,试验组在此基础上给予NIPPV治疗。比较两组的治疗效果。结果治疗后,两组Borg、APACHEⅡ评分均显著降低,且试验组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组PaO_(2)、SaO_(2)均显著升高,PaCO_(2)均显著降低,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组TNF-α、IL-6、IL-10水平均显著改善,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的FEV1、FVC、PEF、FEV1/FVC均显著升高,且试验组高于对照组,差异具有统计学意义(P<0.05)。结论NIPPV治疗COPD合并呼吸衰竭患者的效果显著,可缓解呼吸困难症状,减轻疾病严重程度,改善炎症因子水平及肺功能指标。

Objective To investigate the clinical effect of non-invasive positive pressure ventilation(NIPPV)in the treatment of chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods From November 2019 to March 2021,60 patients with COPD complicated with respiratory failure admitted in our hospital were selected as the research objects and divided into control group(n=30)and experimental group(n=30)according to the order of treatment.The control group was given conventional symptomatic treatment,and the experimental group was given NIPPV treatment on this basis.The therapeutic effects of the two groups were compared.Results After treatment,Borg and APACHEⅡscores in the two groups significantly decreased,those in the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,PaO_(2) and SaO_(2) in the two groups were significantly increased,while PaCO_(2) significantly decreased,those in the experimental group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6 and IL-10 in the two groups significantly improved,those in the experimental group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,FEV1,FVC,PEF and FEV1/FVC in the two groups significantly increased,and those in the experimental group were higher than the control group,the differences were statistically significant(P<0.05).Conclusion NIPPV in the treatment of COPD patients with respiratory failure has a significant effect,which can relieve the symptoms of dyspnea,reduce the severity of the disease,improve the levels of inflammatory factors and the lung function indexes.