抗-CCP联合AKA检测在类风湿关节炎早期诊断中的价值

Value of anti-CCP combined with AKA detection in early diagnosis of rheumatoid arthritis

目的探讨抗环瓜氨酸肽(抗-CCP)联合抗角蛋白抗体(AKA)检测在类风湿关节炎早期诊断中的价值。方法选取2014年3月12日至2019年10月20日的85例疑似类风湿关节炎患者(关节炎组)、85例健康体检者(健康组)、85例其他自身免疫性疾病患者(免疫性组)作为研究对象。受检者均进行抗-CCP、AKA检测,比较三组的抗-CCP水平、抗-CCP阳性率、AKA阳性率,并分析各种诊断方式对类风湿关节炎的诊断结果。结果关节炎组的抗-CCP水平、抗-CCP阳性率、AKA阳性率均高于免疫性组、健康组,且免疫性组高于健康组,差异具有统计学意义(P<0.05)。抗-CCP联合AKA诊断的灵敏度为98.67%(74/75),特异度为100.00%(10/10),漏诊率为1.33%(1/75),误诊率为0.00%(0/10)。结论抗-CCP联合AKA检测在类风湿关节炎早期诊断中具有较高灵敏度和特异度,对疾病发生、发展、预后评估有一定意义。

Objective To explore the value of anti-cyclic citrullinated peptide(anti-CCP)combined with anti-keratin antibody(AKA)detection in early diagnosis of rheumatoid arthritis.Methods From March 12,2014 to October 20,2019,85 patients with suspected rheumatoid arthritis(arthritis group),85 healthy physical examination people(healthy group)and 85 patients with other autoimmune diseases(immune group)were selected as the research objects.All objects were tested anti-CCP and AKA.The levels of anti-CCP,positive rates of anti-CCP and AKA were compared among the three groups.The diagnostic resuits of various diagnostic methods for rheumatoid arthritis were analyzed.Results The levels of anti-CCP,positive rates of anti-CCP and AKA in the arthritis group were higher than those in the immune group and the healthy group,those in the immune group were higher than the healthy group,and the differences were statistically significant(P<0.05).The sensitivity,specificity,missed diagnosis rate and misdiagnosis rate of anti-CCP combined with AKA were 98.67%(74/75),100.00%(10/10),1.33%(1/75)and 0.00%(0/10),respectively.Conclusion Anti-CCP combined with AKA detection has high sensitivity and specificity in early diagnosis of rheumatoid arthritis,which has certain significance in the occurrence,development and prognosis of the disease.