具有MSI-H特征的结直肠癌研究进展

Research progress of colorectal cancer with MSI-H characteristics

结直肠癌(CRC)的发生被证明与微卫星不稳定(MSI)息息相关。临床上通过免疫组化(IHC)、聚合酶链式反应(PCR)以及新一代测序技术(NGS)来检测是否存在MSI。MSI的状态可以预测CRC的转归情况。目前认为高度微卫星不稳定(MSI-H)的CRC患者拥有较为不同的临床特点,其预后往往更好,能受益于免疫治疗。免疫治疗或将跻身为具有MSI-H特征的CRC患者的一线方案。

The occurrence of colorectal cancer(CRC)has been shown to be closely related to microsatellite instability(MSI).In clinical,immunohistochemistry(IHC),polymerase chain reaction(PCR)and next-generation sequencing(NGS)are used to detect the presence of MSI or no.The status of MSI has the capable of predicting the prognosis of CRC.At present,it is believed that CRC patients with microsatellite instability-high(MSI-H)have different clinical characteristics,their prognosis is often better,and the patients can benefit from immunotherapy.Immunotherapy is prospective to be the first-line therapy for CRC patients with MSI-H characteristics.