抗棒环状型抗核抗体在非肝炎病毒感染患者中的临床意义探讨

Clinical significance of anti-rods and rings pattern in non-hepatitis virus infection

目的分析抗棒环状型抗核抗体(anti-RR)在非肝炎病毒感染患者的临床特征并探讨其临床意义。方法纳入德阳市人民医院66例anti-RR阳性患者,将其分为代谢性疾病组(32例)与非代谢性疾病组(34例)。收集患者资料、实验室指标和随访滴度,分析上述资料在代谢性疾病组与非代谢性疾病组的分布差异以及影响滴度变化的危险因素。结果代谢性疾病组血糖、三酰甘油(TG)、γ-谷氨酰转移酶、α-L-盐藻糖苷酶、血尿酸水平和红细胞分布宽度均高于非代谢性疾病组,内生肌酐清除率低于非代谢性疾病组,差异均有统计学意义(P<0.05)。二分类变量Logistic回归分析显示,TG是anti-RR滴度升高的危险因素[OR=3.679(95%CI:1.467~24.779)],P<0.05)。结论anti-RR在非肝炎病毒感染患者中与代谢性疾病的多项临床实验室指标异常相关。高TG水平是anti-RR滴度升高的危险因素,anti-RR滴度的升高与代谢性疾病有关,特别是与TG的代谢异常密切相关,值得临床医生关注。

Objective To analyze the clinical characteristics of anti-rods and rings(anti-RR)pattern in patients with non-hepatitis virus infection and investigate its clinical significance.Methods A total of sixty-six anti-RR positive patients from Deyang People′s Hospital were enrolled and divided into metabolic disease group(32 cases)and non-metabolic disease group(34 cases).The data of patients,laboratory parameters and follow-up titer were collected,and the distribution differences of the above data between metabolic disease group and non-metabolic disease group were analyzed,as well as the risk factors of titer change.Results The blood glucose,triacylglycerol(TG),gamma-glutamyltransferase,α-L-alcosidase,blood uric acid level and red blood cell distribution width in the metabolic disease group were higher than those in the non-metabolic disease group,and endogenous creatinine clearance rate was lower than that in the non-metabolic disease group,the differences were statistically significant(P<0.05).TG was a risk factor for the increase of anti RR titer[OR=3.679(95%CI:1.467-24.779),P<0.05].Conclusion Anti-RR is abnormally related to many clinical laboratory indicators of metabolic diseases in patients with non-hepatitis virus infection.High TG level is a risk factor for the increase of anti-RR titer,the increase of anti-RR titer is related to metabolic diseases,especially closely related to the abnormal metabolism of TG,which deserves the attention of clinicians.