血浆OPN、VEGF与老年冠心病患者冠状动脉侧支循环形成的相关性研究

Study on the correlation between plasma OPN,VEGF and coronary collateral circulation in elderly patients with coronary heart disease

目的探讨血浆骨桥蛋白(OPN)、血管内皮生长因子(VEGF)与老年冠心病(CHD)患者冠状动脉侧支循环(CCC)形成的关系。方法回顾性选择该院2018年9月至2020年5月收治的老年CHD患者110例作为研究对象,根据Rentrop分级法评估CCC形成情况,将患者分为无CCC组(52例)和CCC组(58例),比较2组血浆OPN、VEGF水平,分析老年CHD患者CCC形成的影响因素,血浆OPN、VEGF水平对CCC形成及CCC形成不良的评估价值,以及OPN水平与VEGF的相关性。结果CCC组血浆OPN、VEGF水平较无CCC组明显增高(P<0.05)。血浆OPN、VEGF单独和联合检测对CCC形成及CCC形成不良均有一定评估价值(P<0.05)。血浆OPN水平与VEGF呈正相关(r=0.801,P<0.05)。结论老年CHD患者中CCC形成者的血浆OPN、VEGF水平较无CCC形成者明显升高,二者对CCC形成及CCC形成不良有一定评估价值。

Objective To explore the relationship between plasma osteopontin(OPN),vascular endothelial growth factor(VEGF)and coronary collateral circulation(CCC)in elderly patients with coronary heart disease(CHD).Methods A total of 110 elderly patients with CHD admitted to the hospital from September 2018 to May 2020 were retrospectively selected as the research objects.The formation of CCC was assessed according to the Rentrop classification method,and the patients were divided into non-CCC group(52 cases)and CCC group(58 cases).The plasma levels of OPN and VEGF were compared between the two groups.The influencing factors of CCC formation in elderly CHD patients,the evaluation value of plasma levels of OPN and VEGF on CCC formation and poor CCC formation,as well as the correlation between OPN levels and VEGF were analyzed.Results The plasma levels of OPN and VEGF in the CCC group were significantly higher than those in the non-CCC group(P<0.05).Plasma OPN and VEGF alone and combined detection have certain evaluation value for CCC formation and poor CCC formation(P<0.05).The plasma level of OPN was positively correlated with VEGF(r=0.801,P<0.05).Conclusion The plasma levels of OPN and VEGF in elderly CHD patients with CCC formation are significantly higher than those without CCC formation,and both of them have a certain evaluation value for CCC formation and poor CCC formation.