摘要
从药物的作用靶点改变、药物泵的高表达、生物膜的形成、囊泡的产生、钙信号传导途径、改变甾醇导入6个方面综述造成外阴阴道假丝酵母菌病的白念珠菌的主要耐药机制研究进展,旨在为进一步开展其耐药机制研究及指导临床合理使用抗真菌药物提供理论依据。
This review summarizes the research progress on the drug resistance mechanisms of Candida albicans(CA) causing vulvovaginal candidiasis from 6 aspects, including drug target change, drug pump high expression, biofilm formation, vesicle formation, calcium signaling pathway and altered sterol introduction, in order to provide theoretical basis for further research on drug resistance mechanism of CA and guidance for rational use of antifungal drugs in clinical practice.
作者
周晓涵
宁玉梅
祝秀芝
ZHOU Xiaohan;NING Yumei;ZHU Xiuzhi(The Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310052,China;Zhejiang Maternal,Child and Reproductive Health Center,Hangzhou,Zhejiang 310012,China;Department of Gynecology and Obstetrics,the Second Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310000,China)
出处
《上海中医药杂志》
2021年第5期90-93,101,共5页
Shanghai Journal of Traditional Chinese Medicine
基金
浙江省科技厅科技计划项目(2017ZQ015)。
关键词
白念珠菌
耐药机制
外排泵
生物膜
综述
Candida albicans
drug resistance
efflux pump
bio?lms
review
