磷酸肌酸钠在急性心肌梗死介入术后心力衰竭患者中的应用价值

Value of Sodium Creatine Phosphate in the Treatment of Heart Failure after Interventional Therapy in Patients with Acute Myocardial Infarction

目的探讨磷酸肌酸钠在急性心肌梗死介入术后心力衰竭患者中的应用价值。方法选取2016年1月至2019年7月医院收治的60例急性心肌梗死介入术后心力衰竭患者,采用随机数字表法将患者分为对照组与观察组,各30例。对照组采用常规治疗方式,观察组在对照组基础上采用磷酸肌酸钠治疗,对比两组患者治疗前后的肌钙蛋白、超敏C反应蛋白及脑钠肽前体水平,通过心电图观察两组患者的心功能指标,评估两组的治疗效果及再住院率。结果两组患者治疗前的肌钙蛋白、超敏C反应蛋白、脑钠肽前体水平对比无差异(P>0.05);治疗后,两组患者的肌钙蛋白、超敏C反应蛋白、脑钠肽前体水平较治疗前均得以改善,且观察组改善效果明显优于对照组(P<0.05);观察组左室射血分数高于对照组,左心室收缩末期内径及左心室舒张末期内径低于对照组(P<0.05);观察组治疗总有效率显著高于对照组,再住院率显著低于对照组(P<0.05)。结论针对急性心肌梗死介入术后心力衰竭患者,在常规治疗的基础上采用磷酸肌酸钠治疗能有效降低患者的肌钙蛋白、超敏C反应蛋白及脑钠肽前体水平,改善患者的心功能,降低患者再住院率。

Objective To evaluate the value of sodium creatine phosphate in the treatment of heart failure after interventional therapy in patients with acute myocardial infarction.Methods From January 2016 to July 2019,60 patients with heart failure after interventional acute myocardial infarction were selected.The patients were divided into a control group and an observation group,30 cases in each group,using a random number table method.The control group was treated with routine treatment,the observation group was treated with sodium creatine phosphate on the basis of the control group.The levels of troponin,hypersensitive C reactive protein and brain natriuretic peptide precursor before and after treatment were compared between the two groups,cardiac function indexes were observed by electrocardiogram to evaluate the therapeutic effect and rehospitalization rate of the two groups.Results There was no difference in the levels of troponin,high-sensitivity C-reactive protein,and brain natriuretic peptide before treatment between the two groups of patients(P>0.05);after treatment,the two groups of patients'troponin,high-sensitivity C-reactive protein,and brain sodium The levels of peptide precursors were improved compared to before treatment,and the improvement effect of the observation group was significantly better than that of the control group(P<0.05);the left ventricular ejection fraction of the observation group was higher than that of the control group,the left ventricular end-systolic diameter and left ventricular end-diastolic diameter Lower than the control group(P<0.05);the total effective rate of treatment in the observation group was significantly higher than that of the control group,and the rehospitalization rate was significantly lower than that of the control group(P<0.05).Conclusion For patients with heart failure after interventional acute myocardial infarction,the use of creatine phosphate sodium treatment on the basis of conventional treatment can effectively reduce the levels of troponin,high-sensitivity C-reactive protein and pro-brain natriuretic peptide,and improve the patient's cardiac function,Reduce the patient's rehospitalization rate.Sodium creatine phosphate treatment can effectively reduce the levels of troponin,hypersensitive C reactive protein and brain natriuretic peptide precursors,improve the cardiac function and reduce the rate of rehospitalization.