抗生素联合糖皮质激素对中老年慢性阻塞性肺疾病患者的疗效

Therapeutic Effect of Antibiotic Combined with Glucocorticoid on Middle-aged and Elderly Patients with Chronic Obstructive Pulmonary Disease

目的分析抗生素联合糖皮质激素对中老年慢性阻塞性肺疾病患者的疗效。方法选取本院2018年1月至2019年4月收治的144例中老年慢性阻塞性肺疾病患者,遵循随机分组法将其分为两组,每组72例。两组患者均给予卧床休息、平喘、祛痰、吸氧等常规治疗,对照组给予头孢呋辛钠治疗,观察组在对照组基础上联合应用糖皮质激素治疗。比较两组的治疗效果。结果观察组治疗总有效率高于对照组(P<0.05)。治疗前,两组的FVC、FEV_(1)、MVV、TV水平对比,差异无统计学意义(P>0.05);治疗7 d后,两组FVC、FEV_(1)、MVV、TV水平均较治疗前改善(P<0.05),且观察组FVC、FEV_(1)、MVV、TV水平高于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论针对中老年慢性阻塞性肺疾病患者联合应用抗生素、糖皮质激素治疗的效果显著,肺功能改善明显,安全性高。

Objective To analyze the effect of antibiotic combined with glucocorticoid on the chronic obstructive pulmonary disease in the middle-aged and the elderly.Methods From January 2018 to April 2019,144 middle-aged and old-aged patients with chronic obstructive pulmonary emphysema were treated with a random grouping method,and they were divided into two groups,72 cases in each group.Patients in both groups were given bed rest,asthma,expectoration,and oxygen inhalation.The control group was given cefuroxime sodium therapy,and the observation group was given glucocorticoid therapy on the basis of the control group.Compare the treatment effects of the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Before medication,the levels of FVC,FEV_(1),MVV,and TV between the two groups were not statistically significant(P>0.05);after 7 days of medication,the levels of FVC,FEV_(1),MVV,and TV in the two groups were improved compared with those before medication(P<0.05),and the levels of FVC,FEV_(1),MVV,and TV in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion For middle-aged and elderly patients with chronic obstructive pulmonary disease,the combined application of antibiotics and glucocorticoid therapy has a significant effect,and the lung function is significantly improved,and the safety is high.