声动力疗法在肿瘤治疗中的研究进展

Progress of sonodynamic therapy in treatment of tumors

超声是一种频率>20 kHz的机械波,需要弹性介质传输能量,可以安全地穿透组织而不出现明显衰减。声动力疗法是基于超声发展起来的新兴无创治疗方法,主要利用低强度超声激活声敏剂,促使其产生细胞毒性的活性氧杀伤细胞。与光动力疗法相比,声动力疗法克服了光对深部肿瘤穿透性较低的局限性。此外,它还可以联合光热治疗、化疗、免疫治疗和气体疗法协同治疗肿瘤。文章旨在论述声动力疗法在肿瘤治疗领域的最新进展。

Ultrasound,as a mechanical wave with frequencies>20 kHz,needs an elastic medium to transmit energy,and it can safely penetrate into the tissues without significant attenuation.Sonodynamic therapy is a new noninvasive therapy based on ultrasound,and it mainly uses low-intensity ultrasound to activate sonosensitizers to produce cytotoxic reactive oxygen species to kill cells.Compared with photodynamic therapy,sonodynamic therapy overcomes the limitation of low penetration depth of light for deep tumors.In addition,sonodynamic therapy can be combined with photothermal therapy,chemotherapy,immunotherapy and gas therapy for synergistic therapy of tumors.This review aims to discuss the latest development of sonodynamic therapy in the field of tumor treatment.