地塞米松治疗小儿支原体感染致大叶性肺炎的效果分析

Analysis of the Effect of Dexamethasone on the Treatment of Lobar Pneumonia Caused by Mycoplasma Infection in Children

目的分析地塞米松治疗小儿支原体感染致大叶性肺炎的临床效果。方法选择2019年1月—2020年1月治疗的支原体感染致大叶性肺炎患儿94例,按随机数字表法将其分为两组,各47例。入选患儿均接受抗感染、退热及止咳平喘等常规治疗,对照组给予阿奇霉素治疗,观察组于对照组基础上接受地塞米松治疗。对比两组临床疗效、炎性因子指标[降钙素原(PCT)、白介素-6(IL-6)]及不良反应。结果观察组总有效率(95.74%)高于对照组(80.85%),治疗后PCT(0.15±0.04)ng/mL、IL-6(5.42±2.19)ng/L低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论地塞米松是治疗小儿支原体感染致大叶性肺炎的安全有效药物,能够改善患儿症状,消除炎症反应,且药物副作用少,能够为支原体感染致大叶性肺炎治疗方案的制定提供依据。

Objective To analyze the clinical effect of dexamethasone in the treatment of lobar pneumonia caused by mycoplasma infection in children.Methods 94 children with lobar pneumonia caused by mycoplasma infection treated in our hospital from January 2019 to January 2020 were selected and randomly divided into two groups,47 cases in each group.The selected children all received conventional treatments such as anti-infection,antipyretic,antitussive and antiasthmatic,the control group was given azithromycin,and the observation group received dexamethasone treatment based on the control group.The clinical efficacy,inflammatory factor indicators and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(95.74%)was higher than that of the control group(80.85%),with significant difference(P<0.05).After treatment,PCT was(0.15±0.04)ng/L in the observation group was higher than that of the control group,IL-6 was(5.42±2.19)ng/L was lower than the control group(P<0.05).The incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Dexamethasone is a safe and effective drug for the treatment of lobar pneumonia caused by mycoplasma infection in children,which can improve the symptoms of children and eliminate the inflammatory reaction,and has fewer side effects.