艰难拟梭菌重命名及相关致病因子研究进展

Research progress of reclassification and virulence factors of Clostridioides difficile

基于表型特征、化学分类学及系统发育学等研究,艰难梭菌已被归入拟梭菌属,并重命名为艰难拟梭菌。近年来,随着多重耐药艰难拟梭菌不断出现,导致抗生素治疗失效以及感染复发病例明显上升。目前欧美部分国家已建立完善的艰难拟梭菌感染监控体系及相应的临床诊疗指南,但我国相关工作起步较晚。同时,我国仍存在抗生素使用不规范甚至滥用等现象,造成艰难拟梭菌感染的防控及诊治面临较大挑战。本研究主要介绍了艰难拟梭菌重命名及相关致病因子研究进展,为在国内修正和规范化使用"艰难拟梭菌"名称、推动国内艰难拟梭菌研究进程及致病机制研究等提供必要的参考依据。

Based on the research of phenotypic characteristics,chemical taxonomy and phylogeny,Clostridium difficile has been classified into the genus Clostridioides and renamed as Clostridioides difficile(C.difficile).In recent years,multi-drug resistant C.difficile infection has caused a significant increase in the number of antibiotic treatment failures and recurrent cases.At present,some European and American countries have established a complete surveillance systems and corresponding clinical diagnosis and treatment guidelines for C.difficile infection,but related works started late in our country.What’s more,a large number of non-standardized antibiotic use,even abuse,still exist in clinical treatment in China,resulting in great challenges for the prevention,control,diagnosis and treatment of C.difficile infection.This study aimed to summarize the reclassification of C.difficile and the research progress of its virulence factors in order to provide reference to revise and standardize the name of Clostridioides difficile,promote domestic research of C.difficile and its pathogenic mechanism.