NLRP3炎症小体在AD发病机制中的作用

The Role of NLRP3 Inflammasome in the Pathogenesis of AD

阿尔茨海默病(AD)是老年人常见的中枢神经退行性疾病,也是最常见的老年痴呆症。目前其发病机制及病因尚未明确,近年来,越来越多的证据显示,神经炎症在AD发病机制中起着核心的作用,其中核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体在AD的神经炎症通路中处于关键位置。本文就NLRP3炎症小体在AD中的作用进行综述。

Alzheimer’s disease(AD)is a common central nervous degenerative disease in the elderly and the most common dementia.At present,its pathogenesis and etiology are not yet clear.In recent years,more and more evidence has shown that neuroinflammation plays a central role in the pathogenesis of AD.Among them,the nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is a key position in the neuroinflammatory pathway of AD.This article reviews the role of NLRP3 inflammasome in AD.