原发性开角型青光眼的危险因素及其治疗研究

Study on the Risk factors and Treatment of Primary Open-angle Glaucoma

随着获得性近视的发病率提高和人口老龄化加重,原发性开角型青光眼(POAG)的患病率逐渐增加,虽然目前该疾病的病因及发病机制尚不明确,但普遍认为与眼压、年龄、中央角膜厚度增厚、高度近视、青光眼家族史等因素密切相关。POAG的治疗除了传统的药物、激光和手术治疗,近年来对于青光眼视神经保护剂的研究、基因治疗和干细胞治疗有了长足的进步,为POAG患者提供了希望。本文就POAG发病的危险因素及其治疗作一综述,以期为临床治疗提供参考。

With the increase in the incidence of acquired myopia and the aging of the population,the prevalence of primary open-angle glaucoma(POAG)is gradually increasing.Although the etiology and pathogenesis of the disease are not yet clear,it is generally believed to be closely related to factors such as intraocular pressure,age,thickening of the central cornea,high myopia,and family history of glaucoma.In addition to traditional drugs,laser and surgical treatments,POAG treatment has made great progress in recent years in the research of glaucoma optic neuroprotectants,gene therapy and stem cell therapy,providing hope for POAG patients.This article reviews the risk factors of POAG and its treatment,in order to provide reference for clinical treatment.