摘要
Phototherapies including photodynamic therapy(PDT)and photothermal therapy(PTT)are the most promising and non-invasive cancer treatments.However,the efficacy of mono-therapy of PDT or PTT is often limited by the phototherapeutic defects such as low light penetration depth of photosensitizers and insufficiency of photothermal agents.Peroxynitrite(ONOO−)has been proved to be an efficient oxidizing and nitrating agent that involves in various physiological and pathological processes.Therefore,ONOO−produced in tumor site could be an effective treatment in cancer therapy.Herein,a novel cyanine dye-based(Cy7)polymer nanoplatform is developed for enhanced phototherapy by in situ producing ONOO−.The Cy7 units in the nanoparticles can not only be served as the photosensitizer to produce reactive oxygen species(ROS)including singlet oxygen and superoxide anion for PDT,but also be used as a heat source for PTT and the release of NO gas from N-nitrosated napthalimide(NORM)at the same time.Since NO can react quickly with superoxide anion to generate ONOO−,the enhanced phototherapy could be achieved by in situ ONOO−produced by PCy7-NO upon exposure to the near infrared(NIR)light.Therefore,the NIR-triggered Cy7-based nanoplatform for ONOO−-enhanced phototherapy may provide a new perspective in cancer therapy.
基金
by the National Natural Science Foundation of China(No.21875063)
the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program(No.19440710600).
