载促进成骨中药活性化合物的研究进展

Research Progress on Active Compounds of Traditional Chinese Medicine for Promoting Osteogenesis

金属钛表面具有较好的生物性能,其植入体在骨组织中具有一定的促成骨作用。然而在植入体被整合到骨组织的过程中,骨感染、骨缺损、骨质疏松等相关的疾病也相继出现。中药作为预防、治疗和诊断疾病的物质,将其活性化合物应用于钛植入体中发挥促成骨作用是一种很有效的方法。因此构建中药活性化合物载体,研究其加载方式,实现中药与钛植入体表面结合具有非常重要的意义。该文从中药活性化合物的促成骨作用,钛植入体表面载药的载体,药物结合的方式,以及中药活性化合物在钛植入体表面的应用等几个方面进行综述。希望能够将中药活性化合物更好地应用于钛植入体表面,为局部发挥促成骨作用提供新的研究思路。

The surface of titanium has good biological properties, and its implant can promote osteogenesis in bone tissue. However, in the process of implant integration into bone tissue, bone infection, bone defect, osteoporosis, and other related diseases also appear one after another. Traditional Chinese Medicine(TCM) is used to prevent, treat, and diagnose diseases. It is a very effective method to apply its active compounds in titanium implants to promote osteogenesis. Therefore, it is of great significance to construct the carrier for active compounds of TCM, to study its loading mode and to realize the surface combination of TCM and titanium implants. This paper reviews the osteogenic effect of active compounds of TCM, the carrier of drug loading on the surface of titanium implants, the mode of drug binding, and the application of active compounds of TCM on the surface of titanium implant. It is hoped that the active compounds of TCM can be better applied to the surface of titanium implants and provide new research ideas for promoting local osteogenesis.